YY/T 1955-2025 Tissue engineering medical device – Collagen - Terminology
1 Scope
This document defines the terms and definitions of collagen.
This document is applicable to the collagen (including collagen prepared by tissue extraction or genetic recombination) for preparing tissue engineering scaffold materials and related medical device products.
This document is not applicable to the collagen prepared by genetic recombination and without a triple helix structure.
2 Normative references
No normative references are listed in this document.
3 Terms and definitions
For the purposes of this document, the following terms and definitions apply.
3.1
collagen
secreted protein family containing at least 20 genetically different types, mainly playing a structural support role in the body, having a unique triple helix configuration composed of three polypeptide chains (referred to as α chains), and having certain biological functions
[Source: YY/T 1849-2022, 3.1]
3.2
collagen polymer
polymer with advanced structure formed by collagen molecules through self-assembly or polymerization, without introducing exogenous substances (such as cross-linking agents)
3.3
collagen mimetic peptide
specific amino acid sequence of the triple helix structure of collagen, the basic sequence of the triple helix configuration of natural collagen, generally “glycine-proline-hydroxyproline” [(Gly-X-Y)]
3.4
propeptide
non-triple helix structural region at the amino terminus and carboxyl terminus of a single collagen polypeptide chain (α chain) that guide triple helix folding and the formation of procollagen molecules
Note: The propeptide needs to be removed during the formation and self-assembly of collagen fibrils.
3.5
tropocollagen
collagen molecule composed of three α chains with the amino- and carboxyl-terminal propeptides removed (see Figure 1); with intact carboxyl-terminal and amino-terminal telopeptides
Note: The tropocollagen can self-assemble to form a fibrous network.
3.6
procollagen
collagen molecule composed of three carboxylated polypeptide chains (α chains), in which the amino-terminal propeptide and the carboxyl-terminal propeptide of the polypeptide chain remaining intact (see Figure 1).
Foreword i
1 Scope
2 Normative references
3 Terms and definitions
Bibliography
Index
